The clinical description of the disease elephantiasis or filariasis

Some people may also develop hypersensitivity reactions to the small larval parasites microfilariae. Acute attacks in the extremities of persons living in an area endemic for bancroftian filariasis: Recent studies indicate that DEC has no role either in the treatment or prevention of ADLA attacks occurring in cases of lymphedema, which are caused by bacterial infections [ 192439 ].

Elephantiasis – Definition, Signs and Symptoms, Causes, Cure, Images, Parasite

Carefully wash the swollen area with soap and water every day. Although the legs, arms and external genitalia vulva, penis, scrotum are most often affected, elephantiasis can affect any site of the body.

Parasite antigenemia without microfilaremia in bancroftian filariasis. Such body deformities often lead to social stigma and sub-optimal mental health, loss of income-earning opportunities and increased medical expenses for patients and their caretakers. In this technique, radiolabelled albumin or dextran is induced.

If the human link in the chain of infection can be broken, then notionally the disease could be wiped out in a season. Commonly used antibiotics like penicillin, doxycycline, ampicillin, amoxicillin or cotrimoxazole may be given in adequate doses till the infection subsides.

In underdeveloped regions of South America, Central Africa, Asia, the Pacific Islands and the Caribbean, lymphatic obstruction can be caused by lymphatic filariasiswhich is caused by three different species of worms known as Brugia malayi, Brugia timori and Wuchereria bancrofti.

For these worms, diagnosis relies upon skin snips and can be carried out at any time. This Global Programme for Elimination of LF GPELF launched in has 2 arms consisting of a interruption of transmission by annual mass drug administration MDA to prevent LF infection in the communities and b alleviation of disability in those who already have the disease [ 8 ].

Clinical Features, Diagnosis and Pathology

Excessive amounts of fluid may accumulate edema in the affected areas i. Most of the symptoms an infected person experiences are due to the blockage of the lymphatic system by the adult worms and due to the substances excretions and secretions produced by the worms. The X- ray is effective to identify the dead worm in the tissue.

Most infected people are asymptomatic and will never develop clinical symptoms, despite the fact that the parasite damages the lymph system. The use of this drug in chronic and advanced cases of lymphedema is not substantiated since it is now known that there is neither microfilaremia nor live adult parasites during these stages.

Ann Trop Med Parasitol.


Further epidemiological data reviewed since, indicate that preventive chemotherapy was not required in 10 countries. When used in combination with Ivermectin, it shows small effect on microfilariae levels Studies showed that the albendazole in combination with DEC or Ivermectin does not show more effects than the either of these along drugs.

Since the number of parasites parasitemia in the blood is higher during the night, blood samples are best obtained at night. In some cases, it also leads to the tropical pulmonary eosinophilia.

International awareness of similar looking disease podoconiosis is possible before elimination if increased. Lymphoscintigraphy and elephantiasis diagnosis Lymphoscintigraphy is a sensitive technique, where the abnormalities in the lymphatic system can be detected in their early stage, even before the symptoms appear.

DEC kills the microfilariae quickly and injures or kills the adult worms slowly, if at all. Once established, this damage was thought to be irreversible. What is Onchocerca volvulus?

Frequently Asked Questions (FAQs)

Thus primary lymphedema due to congenital anomalies of the lymphatics and secondary lymphedema resulting from malignancy of pelvic structures, irradiation or surgical excision of the lymph nodes or damage caused to the lymphatics due to podoconiosis, are also prone to ADLA attacks [ 38 ].

Most are the result of secondary bacterial skin infection where normal defences have been partially lost due to underlying lymphatic damage. It inhibits the helminth-specific enzyme called fumarate reductase. The skin snips must be free from blood, so it is best to use the sclerocorneal punches or a needle and scalpel.Although elephantiasis is mainly caused by worms, genital elephantiasis could be the result of a sexually transmitted disease by bacteria such as donovanosis or lymphogranuloma venereum (LGV).

These STDs can trigger an immune response which can cause the lymphatic vessels to constrict and stop functioning, eventually developing into elephantiasis. Lymphatic filariasis is suspected to cause lymphoedema or hydrocoele under the age of 10–15 years, but it is proved that the lymphatic filariasis causes the wide range of acute and chronic clinical signs and symptoms.

Lymphatic filariasis is caused by the worms Wuchereria bancrofti, Brugia malayi, and Brugia timori. These worms occupy the lymphatic system, including the lymph nodes; in chronic cases, these worms lead to the syndrome of elephantiasis.

Subcutaneous filariasis is caused by Loa loa (the eye worm), Mansonella streptocerca, and Onchocerca samoilo15.comlty: Infectious disease.

Congenital elephantiasis

Lymphatic filariasis is a parasitic disease caused by microscopic, thread-like worms. Most infected people are asymptomatic and will never develop clinical symptoms, despite the fact that the parasite damages the lymph system. Lymphedema and elephantiasis are not indications for DEC treatment because most people with lymphedema are not.

Onchocerciasis (River blindness), Lymphatic filariasis (Elephantiasis) and Loiasis (Loa loa infection) are all caused by parasitic filarial nematode worms that are transmitted between humans by blood-sucking insects.

Diagnosis of elephantiasis is made based upon a detailed medical history, meticulous clinical evaluation and identification of characteristic symptoms. Microscopic examination to find the microfilaria is the standard method for diagnosing active infection.

The clinical description of the disease elephantiasis or filariasis
Rated 5/5 based on 95 review